产品货号：
Z18497
中文名称：
HSD17B2抗体
英文名称：
Anti-HSD17B2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HSD17B2 Antibody |
| 指标别名 | 17 beta HSD 2;17βHSD2;20 alpha HSD;E2DH;EDH17B2;HSD17;HSD17B2;SDR9C2 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,IHC-F |
| 基因名称 | HSD17B2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human HSD17B2(373-387aa MPRALRMPNYKKKAT). |
| 实际分子量 | 40KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | HSD17B2(17-BETA-HYDROXYSTEROID DEHYDROGENASE II),also called 17-BETA-HSD II,is an anzyme which have 387 amino acids with a predicted molecular weight of 42,782 and associate with the membranes of the endoplasmic reticulum.Its Cytogenetic location is 16q23.3.The type 2 enzyme was capable of catalyzing the interconversion of testosterone and androstenedione,as well as estradiol and estrone.HSD17B2 mRNA was detected in 18 of 42(43%) adenomas but not in prolactinomas.In the human endometrium,inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2.And HSD17B2 activity distinguishing between disease-free and diseased endometria.HSD17B2 efficiently catalyzes the oxidative metabolism of androgens and estrogens,and it is expressed in a large series of human peripheral tissues.The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium. |
| Uniprot ID | P37059 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | hydroxysteroid(17-beta) dehydrogenase 2 |
| 蛋白名全称 | Estradiol 17-beta-dehydrogenase 2 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section (IHC-F) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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